TV Line has some spoilers for the James and Lena pairing 

Question: Still reeling from James and Lena’s kiss on Supergirl. What can you tell me?! –Charlotte

Ausiello: I can’t tell you much, Charlotte, but I’ll say that Monday’s episode wastes no time getting to bottom of what happened between Kara’s best friend and ex during the holidays. Can they blame it on the mistletoe, or are there real feelings there? You’ll have to watch and see!